Regulatory Network in Protein Phosphorylation
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Substrate: IRAK1

Description: Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

Synonyms: IRAK

Ensembl ID: ENSG00000184216

UniprotKB/SwissProt: IRAK1_HUMAN (P51617)

Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IRAK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IRAK1IRAK1_HUMANT66RSGQR T ASVLW 18.52%IRAK1 HPRD:02235(in vitro)  ViewAnalyzing
2IRAK1IRAK1_HUMANT66RSGQR T ASVLW 18.52%AKT1 HPRD:02235(in vitro)  ViewAnalyzing
3IRAK1IRAK1_HUMANT66RSGQR T ASVLW 18.52%IRAK1 HPRD:02235(in vivo)  ViewAnalyzing
4IRAK1IRAK1_HUMANT100ARDII T AWHPP 24.83%AKT1 HPRD:02235(in vitro)  ViewAnalyzing
5IRAK1IRAK1_HUMANT100ARDII T AWHPP 24.83%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6IRAK1IRAK1_HUMANT209EISRG T HNFSE 16.73%IRAK1 Phospho.ELM 7.0  ViewAnalyzing
7IRAK1IRAK1_HUMANS376SPSQS S MVART 15.05%IRAK1 HPRD:02235(in vitro)  ViewAnalyzing
8IRAK1IRAK1_HUMANS376SPSQS S MVART 15.05%IRAK4 Phospho.ELM 7.0  ViewAnalyzing
9IRAK1IRAK1_HUMANS376SPSQS S MVART 15.05%IRAK4 HPRD:02235(in vitro)  ViewAnalyzing
10IRAK1IRAK1_HUMANT387QTVRG T LAYLP 9.54%IRAK4 HPRD:02235(in vitro)  ViewAnalyzing
11IRAK1IRAK1_HUMANT387QTVRG T LAYLP 9.54%IRAK1 Phospho.ELM 7.0  ViewAnalyzing
12IRAK1IRAK1_HUMANT387QTVRG T LAYLP 9.54%IRAK1 HPRD:02235(in vitro)  ViewAnalyzing
13IRAK1IRAK1_HUMANT387QTVRG T LAYLP 9.54%IRAK4 Phospho.ELM 7.0  ViewAnalyzing
14IRAK1IRAK1_HUMANS568PLAAP S GASAQ 42.12% Phospho.ELM 7.0View   
15IRAK1IRAK1_HUMANS568PLAAP S GASAQ 42.12% Swiss-Prot 55.0 View