|Description: Cofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18).|
Ensembl ID: ENSG00000172757
UniprotKB/SwissProt: COF1_HUMAN (P23528)
Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.