Regulatory Network in Protein Phosphorylation
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Substrate: CFL2

Description: Cofilin-2 (Cofilin, muscle isoform).

Ensembl ID: ENSG00000165410

UniprotKB/SwissProt: COF2_HUMAN (Q9Y281)

Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CFL2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CFL2COF2_HUMANS3---MA S GVTVN 32.28% Swiss-Prot 55.0 View   
2CFL2COF2_HUMANS3---MA S GVTVN 32.28%LIMK1 HPRD:03262(in vivo)  ViewAnalyzing
3CFL2COF2_HUMANS3---MA S GVTVN 32.28%LIMK1 Phospho.ELM 7.0  ViewAnalyzing
4CFL2COF2_HUMANS3---MA S GVTVN 32.28%LIMK1 HPRD:03262(in vitro)  ViewAnalyzing
5CFL2COF2_HUMANS24KVRKS S TQEEI 36.83% Swiss-Prot 55.0 (Similarity)View   
6CFL2COF2_HUMANS24KVRKS S TQEEI 36.83%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
7CFL2COF2_HUMANY89LYDAT Y ETKES 24.26% Swiss-Prot 55.0 View