Regulatory Network in Protein Phosphorylation
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Substrate: CFL1

Description: Cofilin-1 (Cofilin, non-muscle isoform) (18 kDa phosphoprotein) (p18).

Synonyms: CFL

Ensembl ID: ENSG00000172757

UniprotKB/SwissProt: COF1_HUMAN (P23528)

Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
PDB:1Q8G
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CFL1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CFL1COF1_HUMANS3---MA S GVAVS 32.28%LIMK1 Phospho.ELM 7.0  ViewAnalyzing
2CFL1COF1_HUMANS3---MA S GVAVS 32.28%TESK1 Phospho.ELM 7.0  ViewAnalyzing
3CFL1COF1_HUMANS3---MA S GVAVS 32.28%TESK2 HPRD:03261(in vitro;in vivo)  ViewAnalyzing
4CFL1COF1_HUMANS3---MA S GVAVS 32.28%TESK2 Phospho.ELM 7.0  ViewAnalyzing
5CFL1COF1_HUMANS3---MA S GVAVS 32.28%LIMK1 HPRD:03261(in vitro;in vivo)  ViewAnalyzing
6CFL1COF1_HUMANS3---MA S GVAVS 32.28%LIMK2 HPRD:03261(in vitro;in vivo)  ViewAnalyzing
7CFL1COF1_HUMANS3---MA S GVAVS 32.28%LIMK2 Phospho.ELM 7.0  ViewAnalyzing
8CFL1COF1_HUMANS3---MA S GVAVS 32.28%NRK HPRD:03261(in vitro;in vivo)  ViewAnalyzing
9CFL1COF1_HUMANS3---MA S GVAVS 32.28%NRK Swiss-Prot 55.0   ViewAnalyzing
10CFL1COF1_HUMANS3---MA S GVAVS 32.28%TESK1 HPRD:03261(in vitro;in vivo)  ViewAnalyzing
11CFL1COF1_HUMANT25VRKSS T PEEVK 41.64% Phospho.ELM 7.0View   
12CFL1COF1_HUMANT25VRKSS T PEEVK 41.64% Swiss-Prot 55.0 View   
13CFL1COF1_HUMANY68TVDDP Y ATFVK 25.85% Phospho.ELM 7.0View   
14CFL1COF1_HUMANY68TVDDP Y ATFVK 25.85% Swiss-Prot 55.0 (Similarity)View   
15CFL1COF1_HUMANY140LQANC Y EEVKD 18.22% Phospho.ELM 7.0View   
16CFL1COF1_HUMANY140LQANC Y EEVKD 18.22% Swiss-Prot 55.0 View   
17CFL1COF1_HUMANS156EKLGG S AVISL 19.98% Swiss-Prot 55.0 View