Regulatory Network in Protein Phosphorylation
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Substrate: MAP3K11

Description: Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase).

Synonyms: MLK3, PTK1, SPRK

Ensembl ID: ENSG00000173327

UniprotKB/SwissProt: M3K11_HUMAN (Q16584)

Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome. Note=Location is cell cycle dependent.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP3K11

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP3K11M3K11_HUMANT277REWHK T TQMSA 14.90%MLK3 HPRD:02502(in vitro)  ViewAnalyzing
2MAP3K11M3K11_HUMANT277REWHK T TQMSA 14.90%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
3MAP3K11M3K11_HUMANT277REWHK T TQMSA 14.90%MLK3(MAP3K11) Phospho.ELM 7.0 ViewAnalyzing
4MAP3K11M3K11_HUMANS281KTTQM S AAGTY 12.73%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
5MAP3K11M3K11_HUMANS281KTTQM S AAGTY 12.73%HPK1(MAP4K1) Swiss-Prot 55.0  ViewAnalyzing
6MAP3K11M3K11_HUMANS281KTTQM S AAGTY 12.73%HPK1(MAP4K1) Phospho.ELM 7.0 ViewAnalyzing
7MAP3K11M3K11_HUMANS281KTTQM S AAGTY 12.73%HPK1 HPRD:02502(in vitro)  ViewAnalyzing
8MAP3K11M3K11_HUMANS281KTTQM S AAGTY 12.73%MLK3(MAP3K11) Phospho.ELM 7.0 ViewAnalyzing
9MAP3K11M3K11_HUMANS507ITVQA S PGLDR 11.47% Swiss-Prot 55.0 View   
10MAP3K11M3K11_HUMANS524VGPGD S PTFPR 31.58% HPRD:02502(in vivo)View   
11MAP3K11M3K11_HUMANS524VGPGD S PTFPR 31.58% Phospho.ELM 7.0View   
12MAP3K11M3K11_HUMANS524VGPGD S PTFPR 31.58% Swiss-Prot 55.0 View   
13MAP3K11M3K11_HUMANS555RRLED S SNGER 19.14% Swiss-Prot 55.0 View   
14MAP3K11M3K11_HUMANS555RRLED S SNGER 19.14% HPRD:02502(in vivo)View   
15MAP3K11M3K11_HUMANS555RRLED S SNGER 19.14% Phospho.ELM 7.0View   
16MAP3K11M3K11_HUMANS556RLEDS S NGERR 62.26% Phospho.ELM 7.0View   
17MAP3K11M3K11_HUMANS556RLEDS S NGERR 62.26% Swiss-Prot 55.0 View   
18MAP3K11M3K11_HUMANS556RLEDS S NGERR 62.26% HPRD:02502(in vivo)View   
19MAP3K11M3K11_HUMANS654TALLA S LGLGR 23.96% Swiss-Prot 55.0 View   
20MAP3K11M3K11_HUMANS654TALLA S LGLGR 23.96% Phospho.ELM 7.0View   
21MAP3K11M3K11_HUMANS654TALLA S LGLGR 23.96% HPRD:02502(in vivo)View   
22MAP3K11M3K11_HUMANS674RERGE S PTTPP 30.30%AKT_group Phospho.ELM 7.0 ViewAnalyzing
23MAP3K11M3K11_HUMANS674RERGE S PTTPP 30.30%AKT1 HPRD:02502(in vitro;in vivo)  ViewAnalyzing
24MAP3K11M3K11_HUMANS705LKTPD S PPTPA 33.70% HPRD:02502(in vivo)View   
25MAP3K11M3K11_HUMANS705LKTPD S PPTPA 33.70% Phospho.ELM 7.0View   
26MAP3K11M3K11_HUMANS705LKTPD S PPTPA 33.70% Swiss-Prot 55.0 View   
27MAP3K11M3K11_HUMANS724PVGQR S AKSPR 31.96% HPRD:02502(in vivo)View   
28MAP3K11M3K11_HUMANS724PVGQR S AKSPR 31.96% Swiss-Prot 55.0 View   
29MAP3K11M3K11_HUMANS724PVGQR S AKSPR 31.96% Phospho.ELM 7.0View   
30MAP3K11M3K11_HUMANS727QRSAK S PRREE 24.29% HPRD:02502(in vivo)View   
31MAP3K11M3K11_HUMANS727QRSAK S PRREE 24.29% Swiss-Prot 55.0 View   
32MAP3K11M3K11_HUMANS727QRSAK S PRREE 24.29% Phospho.ELM 7.0View   
33MAP3K11M3K11_HUMANT738EPRGG T VSPPP 22.19% Swiss-Prot 55.0 View   
34MAP3K11M3K11_HUMANS740RGGTV S PPPGT 31.37% Swiss-Prot 55.0 View   
35MAP3K11M3K11_HUMANS740RGGTV S PPPGT 31.37% HPRD:02502(in vivo)View   
36MAP3K11M3K11_HUMANS746PPPGT S RSAPG 30.10% Swiss-Prot 55.0 View   
37MAP3K11M3K11_HUMANS758PGTPR S PPLGL 31.88% Phospho.ELM 7.0View   
38MAP3K11M3K11_HUMANS758PGTPR S PPLGL 31.88% HPRD:02502(in vivo)View   
39MAP3K11M3K11_HUMANS758PGTPR S PPLGL 31.88% Swiss-Prot 55.0 View   
40MAP3K11M3K11_HUMANS770SRPRP S PLRSR 37.53% HPRD:02502(in vivo)View   
41MAP3K11M3K11_HUMANS770SRPRP S PLRSR 37.53% Swiss-Prot 55.0 View   
42MAP3K11M3K11_HUMANS770SRPRP S PLRSR 37.53% Phospho.ELM 7.0View   
43MAP3K11M3K11_HUMANS793PSPLP S PQPAP 43.80% HPRD:02502(in vivo)View   
44MAP3K11M3K11_HUMANS793PSPLP S PQPAP 43.80% Swiss-Prot 55.0 View   
45MAP3K11M3K11_HUMANS793PSPLP S PQPAP 43.80% Phospho.ELM 7.0View