Regulatory Network in Protein Phosphorylation
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Substrate: MAP2K4

Description: Dual specificity mitogen-activated protein kinase kinase 4(EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-JunN-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

Synonyms: JNKK1, MKK4, PRKMK4, SERK1

Ensembl ID: ENSG00000065559

UniprotKB/SwissProt: MP2K4_HUMAN (P45985)

Function: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP2K4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP2K4MP2K4_HUMANS80RLRTH S IESSG 27.69%AKT1 HPRD:03213(in vitro;in vivo)  ViewAnalyzing
2MAP2K4MP2K4_HUMANS80RLRTH S IESSG 27.69%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3MAP2K4MP2K4_HUMANS257GQLVD S IAKTR 19.57%MAP2K4 HPRD:03213(in vivo)  ViewAnalyzing
4MAP2K4MP2K4_HUMANS257GQLVD S IAKTR 19.57%MAP2K4 Phospho.ELM 7.0  ViewAnalyzing
5MAP2K4MP2K4_HUMANT261DSIAK T RDAGC 25.43%MLK3(MAP3K11) Phospho.ELM 7.0 ViewAnalyzing
6MAP2K4MP2K4_HUMANT261DSIAK T RDAGC 25.43%MAP2K4 Phospho.ELM 7.0  ViewAnalyzing
7MAP2K4MP2K4_HUMANT261DSIAK T RDAGC 25.43%MAP2K4 HPRD:03213(in vivo)  ViewAnalyzing
8MAP2K4MP2K4_HUMANT261DSIAK T RDAGC 25.43%MAP3K5 Phospho.ELM 7.0  ViewAnalyzing