Regulatory Network in Protein Phosphorylation
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Substrate: IKBKB

Description: Inhibitor of nuclear factor kappa-B kinase subunit beta (EC beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

Synonyms: IKKB

Ensembl ID: ENSG00000104365

UniprotKB/SwissProt: IKKB_HUMAN (O14920)

Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IKBKB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IKBKBIKKB_HUMANT23KERLG T GGFGN 38.43% Swiss-Prot 55.0 (Similarity)View   
2IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%IKKa HPRD:04462(in vitro;in vivo)  ViewAnalyzing
3IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%PKCt HPRD:04462(in vitro;in vivo)  ViewAnalyzing
4IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%PKCz HPRD:04462(in vitro)  ViewAnalyzing
5IKBKBIKKB_HUMANS177ELDQG S LCTSF 18.03%NIK HPRD:04462(in vitro)  ViewAnalyzing