Regulatory Network in Protein Phosphorylation
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[Back to Kinase TAK1]
Substrate: MAP3K7

Description: Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)(Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1).

Synonyms: TAK1

Ensembl ID: ENSG00000135341

UniprotKB/SwissProt: M3K7_HUMAN (O43318)

Function: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:2EVA
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP3K7

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP3K7M3K7_HUMANT184ACDIQ T HMTNN 17.59%TAK1 HPRD:04011(in vitro)  ViewAnalyzing
2MAP3K7M3K7_HUMANT184ACDIQ T HMTNN 17.59%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
3MAP3K7M3K7_HUMANT184ACDIQ T HMTNN 17.59%MAP3K7 Phospho.ELM 7.0  ViewAnalyzing
4MAP3K7M3K7_HUMANT187IQTHM T NNKGS 28.21%TAK1 HPRD:04011(in vitro)  ViewAnalyzing
5MAP3K7M3K7_HUMANT187IQTHM T NNKGS 28.21%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
6MAP3K7M3K7_HUMANT187IQTHM T NNKGS 28.21%MAP3K7 Phospho.ELM 7.0  ViewAnalyzing
7MAP3K7M3K7_HUMANS192TNNKG S AAWMA 19.20%TAK1 HPRD:04011(in vitro)  ViewAnalyzing
8MAP3K7M3K7_HUMANS192TNNKG S AAWMA 19.20%MAP3K7 Phospho.ELM 7.0  ViewAnalyzing
9MAP3K7M3K7_HUMANS192TNNKG S AAWMA 19.20%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
10MAP3K7M3K7_HUMANS439QPRRR S IQDLT 23.84% Swiss-Prot 55.0 View