|Description: Serine/threonine-protein kinase Chk2 (EC 22.214.171.124) (Cds1).|
Synonyms: CHK2, RAD53
Ensembl ID: ENSG00000183765
UniprotKB/SwissProt: CHK2_HUMAN (O96017)
Function: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 2: Nucleus. Note=Isoform 10 is present throughout the cell. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus.