Regulatory Network in Protein Phosphorylation
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Substrate: SMAD1

Description: Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers againstDPP homolog 1) (Mad-related protein 1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

Synonyms: BSP1, MADH1, MADR1

Ensembl ID: ENSG00000170365

UniprotKB/SwissProt: SMAD1_HUMAN (Q15797)

Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
PDB:1KHU
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SMAD1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SMAD1SMAD1_HUMANS187HPFPH S PNSSY 26.47%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
2SMAD1SMAD1_HUMANS195SSYPN S PGSSS 26.57%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
3SMAD1SMAD1_HUMANS195SSYPN S PGSSS 26.57%Erk2 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
4SMAD1SMAD1_HUMANS206STYPH S PTSSD 25.93%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
5SMAD1SMAD1_HUMANS206STYPH S PTSSD 25.93%Erk2 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
6SMAD1SMAD1_HUMANS214SSDPG S PFQMP 28.12%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
7SMAD1SMAD1_HUMANS214SSDPG S PFQMP 28.12%Erk2 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
8SMAD1SMAD1_HUMANS462PHNPI S SVS 26.41%TGFbR1 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
9SMAD1SMAD1_HUMANS462PHNPI S SVS 26.41%TGFbR1 Phospho.ELM 7.0  ViewAnalyzing
10SMAD1SMAD1_HUMANS462PHNPI S SVS 26.41%ALK2 HPRD:03356(in vitro)  ViewAnalyzing
11SMAD1SMAD1_HUMANS462PHNPI S SVS 26.41%BMPR1B Phospho.ELM 7.0  ViewAnalyzing
12SMAD1SMAD1_HUMANS463HNPIS S VS 27.40%BMPR1B Phospho.ELM 7.0  ViewAnalyzing
13SMAD1SMAD1_HUMANS463HNPIS S VS 27.40%ALK2 HPRD:03356(in vitro)  ViewAnalyzing
14SMAD1SMAD1_HUMANS463HNPIS S VS 27.40% Swiss-Prot 55.0 View   
15SMAD1SMAD1_HUMANS463HNPIS S VS 27.40%TGFbR1 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
16SMAD1SMAD1_HUMANS463HNPIS S VS 27.40%TGFbR1 Phospho.ELM 7.0  ViewAnalyzing
17SMAD1SMAD1_HUMANS465PISSV S  36.13%BMPR1B Phospho.ELM 7.0  ViewAnalyzing
18SMAD1SMAD1_HUMANS465PISSV S  36.13%TGFbR1 HPRD:03356(in vitro;in vivo)  ViewAnalyzing
19SMAD1SMAD1_HUMANS465PISSV S  36.13%TGFbR1 Phospho.ELM 7.0  ViewAnalyzing
20SMAD1SMAD1_HUMANS465PISSV S  36.13% Swiss-Prot 55.0 View   
21SMAD1SMAD1_HUMANS465PISSV S  36.13%ALK2 HPRD:03356(in vitro)  ViewAnalyzing