Regulatory Network in Protein Phosphorylation
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Substrate: STAMBP

Description: STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3domain of STAM).

Synonyms: AMSH

Ensembl ID: ENSG00000124356

UniprotKB/SwissProt: STABP_HUMAN (O95630)

Function: May function as a ubiquitin-protein or polyubiquitin hydrolase. This deubiquitinating enzyme which functions at the endosome, is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STAMBP

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STAMBPSTABP_HUMANS2----M S DHGDV 38.01% Swiss-Prot 55.0 View   
2STAMBPSTABP_HUMANS2----M S DHGDV 38.01%BMPR1B HPRD:05877(in vivo)  ViewAnalyzing
3STAMBPSTABP_HUMANS2----M S DHGDV 38.01% Phospho.ELM 7.0View   
4STAMBPSTABP_HUMANS48IIRMA S IYSEE 16.83% Phospho.ELM 7.0View   
5STAMBPSTABP_HUMANS48IIRMA S IYSEE 16.83%BMPR1B HPRD:05877(in vivo)  ViewAnalyzing
6STAMBPSTABP_HUMANS48IIRMA S IYSEE 16.83% Swiss-Prot 55.0 View   
7STAMBPSTABP_HUMANS243KPGAL S NSESI 37.46% Phospho.ELM 7.0View   
8STAMBPSTABP_HUMANS243KPGAL S NSESI 37.46% Swiss-Prot 55.0 View   
9STAMBPSTABP_HUMANS243KPGAL S NSESI 37.46%BMPR1B HPRD:05877(in vivo)  ViewAnalyzing
10STAMBPSTABP_HUMANS245GALSN S ESIPT 29.37% Phospho.ELM 7.0View   
11STAMBPSTABP_HUMANS245GALSN S ESIPT 29.37% Swiss-Prot 55.0 View   
12STAMBPSTABP_HUMANS245GALSN S ESIPT 29.37%BMPR1B HPRD:05877(in vivo)  ViewAnalyzing
13STAMBPSTABP_HUMANS247LSNSE S IPTID 33.42%BMPR1B HPRD:05877(in vivo)  ViewAnalyzing
14STAMBPSTABP_HUMANS247LSNSE S IPTID 33.42% Swiss-Prot 55.0 View   
15STAMBPSTABP_HUMANS247LSNSE S IPTID 33.42% Phospho.ELM 7.0View