Regulatory Network in Protein Phosphorylation
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The kinase complement of the human genome, the kinome, provided a start point for comprehensive investigation of protein phosphorylation. Manning et al. identified 518 protein kinase genes and 106 protein kinase pseudogenes in human (Manning et al., 2002 Science). Most protein kinases contain a conserved catalytic domain belonging to the eukaryotic protein kinase (ePK) superfamily (all other protein kinases are classified as atypical protein kinases, or aPKs). ePKs are classified into 7 major groups, including AGC, CAMK, CK1, CMGC, STE, TK, and TKL, and are subdivided into families, and sometimes subfamilies, based on the sequence of their ePK domains. All 518 human kinases are listed as following, users can clikc into the URL link to investigate the detail information about the kinase and their substrates.

[All kinases] [Kinase families] [Tree view of kinase families]

 
AGC_____PKBAKT1 AKT2 AKT3
 |_____DMPK_____ROCK ROCK1 ROCK2
 |____GEK DMPK1 DMPK2 MRCKa MRCKb
 |____CRIK CRIK
 |_____GRK_____GRK GPRK7 RHOK GPRK6 GPRK5 GPRK4
 |____BARK BARK1 BARK2
 |_____MAST_____MAST MAST1 MAST2 MAST3 MAST4
 |____MASTL MASTL
 |_____NDR NDR1 NDR2 LATS1 LATS2
 |_____PKA PKACa PKACb PKACg
 |_____PDK1 PDK1
 |_____PKC PKCh PKCa PKCb PKCd PKCe PKCg PKCi PKCt PKCz
 |____Alpha PKCa PKCb PKCg
 |____Delta PKCd PKCt
 |____Eta PKCe PKCh
 |____Iota PKCi PKCz
 |_____PKG PKG1 PKG2
 |_____PKN PKN1 PKN2 PKN3
 |_____RSK_____RSK RSK1 RSK2 RSK3 RSK4
 |____p70 p70S6K p70S6Kb
 |____MSK MSK1 MSK2
 |_____RSKL RSKL1 RSKL2
 |_____RSKR SgK494
 |_____SGK SGK SGK2 SGK3
 |_____YANK YANK1 YANK2 YANK3
 
Atypical_____ABC1ADCK1 ADCK2 ADCK3 ADCK4 ADCK5
 |_____Alpha_____Alpha AlphaK1 AlphaK2 AlphaK3
 |____eEF2K eEF2K
 |____ChaK ChaK1 ChaK2
 |_____BCR BCR
 |_____BRD BRDT BRD2 BRD3 BRD4
 |_____FAST FASTK
 |_____G11 G11(STK19)
 |_____H11 H11
 |_____PDHK_____PDHK PDHK1 PDHK2 PDHK3 PDHK4 BCKDK
 |____BCKDK BCKDK
 |_____PIKK_____TRRAP TRRAP
 |____SMG1 SMG1
 |____ATM ATM ATR
 |____DNAPK DNAPK
 |____FRAP FRAP
 |_____RIO RIOK1 RIOK2 RIOK3
 |_____TAF1 TAF1 TAF1L
 |_____TIF1 TIF1a TIF1b TIF1b
 
CAMK_____CAMK-UniqueVACAMKL STK33
 |_____CAMK1 CaMK1a CaMK1b CaMK1g CaMK1d CaMK4
 |_____CAMK2 CaMK2a CaMK2b CaMK2g CaMK2d
 |_____CAMKL_____NIM1 NIM1
 |____NuaK NuaK1 NuaK2
 |____PASK PASK
 |____QIK QIK QSK SIK
 |____SNRK SNRK
 |____MELK MELK
 |____AMPK AMPKa1 AMPKa2
 |____CHK1 CHK1
 |____CHK2 CHK2
 |____HUNK HUNK
 |____LKB LKB1
 |____MARK MARK1 MARK2 MARK3 MARK4
 |____BRSK BRSK1
 |_____CASK CASK
 |_____DAPK DAPK1 DAPK2 DAPK3 DRAK1 DRAK2
 |_____DCAMKL DCLK1 DCLK2 DCLK3
 |_____MAPKAPK_____MAPKAPK MAPKAPK2 MAPKAPK3 MAPKAPK5
 |____MNK MNK1 MNK2
 |_____MLCK smMLCK TTN caMLCK skMLCK Sgk085
 |_____PHK PHKg1 PHKg2
 |_____PIM PIM1 PIM2 PIM3
 |_____PKD PKD1 PKD2 PKD3
 |_____PSK PSKH1 PSKH2
 |_____SgK495 SgK495
 |_____Trbl Trb1 Trb2 Trb3
 |_____Trio Trad Trio SPEG Obscn
 |_____TSSK TSSK1 TSSK2 TSSK3 TSSK4 SSTK
 
CK1_____CK1CK1a CK1d CK1e CK1g2 CK1g3 CK1a2 CK1g1
 |_____TTBK TTBK1 TTBK2
 |_____VRK VRK1 VRK2 VRK3
 
CMGC_____CDKCDK4 CDK5 CDK6 CDK8 CDK9 CDK10 CDK11
 |____CDK7 CDK7
 |____CDC2 CDC2 CDK2 CDK3
 |____CRK7 CHED CRK7
 |____PCTAIRE PCTAIRE1 PCTAIRE2 PCTAIRE3
 |____PFTAIRE PFTAIRE1 PFTAIRE2
 |____PITSLRE PITSLRE
 |_____CDKL CDKL1 CDKL2 CDKL3 CDKL4 CDKL5
 |_____CK2 CK2a1 CK2a2 CK2al-rs
 |_____CLK CLK1 CLK2 CLK3 CLK4
 |_____DYRK_____PRP4 PRP4
 |____HIPK HIPK1 HIPK2 HIPK3 HIPK4
 |____DYRK DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
 |_____GSK GSK3A GSK3B
 |_____MAPK_____MAPK Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) NLK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13)
 |____JNK JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10)
 |____p38 p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13)
 |____ERK Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15)
 |____nmo NLK
 |_____RCK MAK MOK ICK
 |_____SRPK MSSK1 SRPK1 SRPK2
 
Other_____AURAurA AurB AurC
 |____AurB AurB
 |____AurA AurA
 |_____BUB BUB1 BUBR1
 |_____Bud32 PRPK
 |_____CAMKK_____Meta CaMKK1 CaMKK2
 |_____CDC7 CDC7
 |_____Haspin Haspin
 |_____IKK IKKa IKKb IKKe TBK1
 |_____IRE IRE1 IRE2
 |_____MOS MOS
 |_____KIS KIS
 |_____NAK MPSK1 GAK BIKE AAK1
 |_____NEK NEK1 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK8 NEK9 NEK10 NEK11
 |_____NKF1 SgK110 SgK069 SBK
 |_____NKF2 PINK1
 |_____NKF3 SgK269 SgK223
 |_____NKF4 CLIK1 CLIK1L
 |_____NKF5 SgK307 SgK424
 |_____NRBP NRBP1 NRBP2
 |_____Other-Unique RNAseL SgK396 SgK196
 |_____PEK_____GCN2 GCN2
 |____PKR PKR
 |____PEK PEK
 |____HRI HRI
 |_____PLK PLK1 PLK2 PLK3 PLK4
 |_____SCY1 SCYL1 SCYL2 SCYL3
 |_____SgK071 SgK071
 |_____SgK493 SgK493
 |_____SgK496 SgK496
 |_____Slob Slob
 |_____TBCK TBCK
 |_____TLK TLK1 TLK2
 |_____TOPK PBK
 |_____TTK TTK
 |_____ULK_____ULK ULK1 ULK2 ULK3 ULK4
 |____Fused Fused
 |_____VPS15 PIK3R4
 |_____WEE Wee1 Wee1B MYT1
 |_____WNK Wnk1 Wnk2 Wnk3 Wnk4
 |_____CDPK CDPK
 
RGC_____RGCANPa ANPb CYGD CYGF HSER
 
STE_____STE-UniqueCOT NIK
 |_____STE11_____MAP3K MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8
 |_____STE20_____PAK PAK1 PAK2 PAK3 PAK4 PAK5 PAK6
 |____PAKB PAK4 PAK5 PAK6
 |____PAKA PAK1 PAK2 PAK3
 |____SLK LOK SLK
 |____STLK STLK5 STLK6 STLK6-rs
 |____TAO TAO1 TAO3 TAO3
 |____YSK YSK1 MST3 MST4
 |____KHS KHS1 KHS2 GCK HPK1
 |____FRAY STLK3 OSR1
 |____MSN HGK TNIK NRK MINK
 |____MST MST1 MST2
 |____NinaC MYO3A MYO3B
 |_____STE7_____MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7
 
TK_____AblABL1(Abl) ABL2(ARG)
 |_____Ack ACK TNK1
 |_____ALK ALK LTK
 |_____Axl AXL MER TYRO3
 |_____CCK4 CCK4
 |_____Csk CSK CTK
 |_____DDR DDR1 DDR2
 |_____EGFR EGFR ErbB2 ErbB3 ErbB4
 |_____Eph EphA1 EphA2 EphA3 EphA4 EphA5 EphA6 EphA7 EphA8 EphA10 EphB1 EphB2 EphB3 EphB4 EphB5 EphB6
 |_____FAK FAK PYK2
 |_____Fer_____Fer FER
 |____Fes FES
 |_____FGFR FGFR1 FGFR2 FGFR3 FGFR4
 |_____InsR INSR IRR
 |____IGF1R IGF1R
 |_____JAK_____JakA JAK1 JAK2 JAK3
 |_____TYK_____TYK2 TYK2
 |_____Lmr LMR1 LMR2 LMR3
 |_____Met_____Met MET RON
 |_____Musk MUSK
 |_____PDGFR_____PDGFR PDGFRa PDGFRb
 |____Fms FMS
 |____FLT3 FLT3
 |____Kit KIT
 |_____Ret RET
 |_____Ror ROR1 ROR2
 |_____Ryk RYK
 |_____Sev ROS
 |_____Src_____SRM SRM
 |____BLK BLK
 |____Brk BRK
 |____Fgr FGR
 |____Fyn FYN
 |____HCK HCK
 |____Lck LCK
 |____LYN LYN
 |____Src SRC
 |____YES YES
 |____Frk FRK
 |_____Syk_____SYK SYK
 |____ZAP70 ZAP70
 |_____Tec TXK TEC ITK BMX BTK
 |____BTK BTK
 |____ITK ITK
 |____TXK TXK TEC
 |_____Tie TIE1 TIE2
 |_____TK-Unique SuRTK106
 |_____Trk TRKA TRKB TRKC
 |_____VEGFR FLT1 FLT4 FLT3 KDR
 
TKL_____IRAKIRAK1 IRAK2 IRAK3 IRAK4
 |_____LISK_____TESK TESK1 TESK2
 |____LIMK LIMK1 LIMK2
 |_____LRRK LRRK1 LRRK2
 |_____MLK_____MLK MLK1 MLK2 MLK3 MLK4
 |____LZK LZK DLK
 |____ZAK ZAK
 |____TAK1 TAK1
 |____HH498 HH498
 |____ILK ILK
 |_____RAF_____RAF RAF1 ARAF BRAF
 |____KSR KSR1 KSR2
 |_____RIPK RIPK1 RIPK2 RIPK3 SgK288 ANKRD3
 |_____STKR_____Type1 TGFbR1 ALK7 ALK1 ALK2 ALK4 BMPR1A BMPR1B
 |____Type2 TGFbR2 BMPR2 MISR2 ACTR2 ACTR2B
 |____TGFbR TGFbR1 TGFbR2
 |_____TKL-Unique MLKL