Regulatory Network in Protein Phosphorylation
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Expression Analysis
In this work, the human gene expression samples of Affymetrix GeneChip Human Genome U133 Array Set HG-U133A platform (GPL96) from Gene Expression Omnibus (GEO), consisting of 22283 probe set for 12678 genes, are used to explore the co-coexpression analysis of kinase and substrate genes. However, the first problem we faced is what kind of microarray experiment should be selected for investigating the co-expression of kinase and substrate genes. Without any specific interest and limitation, we decide to focus on the experimental series of microarray with the raw data. Totally 2714 samples within 98 experiment series (GSE) were collected and normalized by RMA package.

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