Regulatory Network in Protein Phosphorylation
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The Cross-validation of the 107 catagorized kinase families

The experimentally verified phosphorylated sites are collected from PhosphoELM and SwissProt. All the 518 kinase genes which were identified by Manning et al. are categorized by their annotated family or subfamily. There are totally 107 kinase familes including more than 300 kinases. The number of phosphorylated sites in human proteins is listed, as well as the number of phosphorylated proteins. Moreover, the sequence logo of each kinase family is presented by using Weblogo.

No.GroupFamilySubfamilyFamily descriptionKinase memberNumber of phosphosites in all speciesSequence logoHMM Sn.HMM Sp.HMM Acc.SVM Acc.Std.
1AGCPKB Protein kinase B AKT1 AKT2 AKT3 89(64)
2AGCDMPKROCK Rho Kinase ROCK1 ROCK2 38(22) 77.586.882.277.95.1
3AGCGRKGRK G-protein coupled Receptor Kinase GPRK7 RHOK GPRK6 GPRK5 GPRK4 84(26) -----
4AGCGRKBARK Beta Adrenergic Receptor Kinase BARK1 BARK2 33(15) 62.185.873.962.72.6
5AGCNDR Nuclear Dbf2-related kinases NDR1 NDR2 LATS1 LATS2 2(2) 1001001006517.5
6AGCPKA Protein kinase A PKACa PKACb PKACg 493(302) 82.483.983.188.31.0
7AGCPDK1 Phosphoinositide-dependent protein kinase PDK1 34(24) 85.381.883.681.52.0
8AGCPKC Protein kinase C PKCh PKCa PKCb PKCd PKCe PKCg PKCi PKCt PKCz 413(234) 61.787.374.580.10.8
9AGCPKG Protein kinase G PKG1 PKG2 42(23) 78.385.581.982.73.0
10AGCPKN Protein kinase N PKN1 PKN2 PKN3 3(1) 7510087.581.36.6
11AGCRSKRSK Ribosomal S6 Kinase RSK1 RSK2 RSK3 RSK4 49(36)
12AGCRSKp70 p70 subfamily of Ribosomal Specific Kinase p70S6K p70S6Kb 9(7) -----
13AGCRSKMSK  MSK1 MSK2 9(4) -----
14AGCSGK Serum and Glucocorticoid Resposive Kinase SGK SGK2 SGK3 20(11) 70.410085.297.30.8
15AtypicalAlpha Ancient family of atypical kinases AlphaK1 AlphaK2 AlphaK3 ChaK1 ChaK2 eEF2k 3(2) 33.310066.74524.9
16AtypicalPDHK Pyruvate Dehydrogenase Kinase PDHK1 PDHK2 PDHK3 PDHK4 BCKDK 4(2) 501007571.2513.2
17AtypicalPIKKATM Ataxia telangiectasia mutated ATM ATR 78(48) 87.995.691.897.20.6
18AtypicalPIKKDNAPK DNA Protein Kinase DNAPK 21(11) 85.795.290.589.53.9
19AtypicalPIKKFRAP FKBP12-rapamycin-associated protein FRAP 15(5) 93.310096.787.76.7
20AtypicalTAF1  TAF1 TAF1L 6(3) 5001007572.57.9
21CAMKCAMK1 CAMK family 1 CaMK1a CaMK1b CaMK1g CaMK1d CaMK4 17(14) 68.290.979.679.85.3
22CAMKCAMK2 CAMK family 2 CaMK2a CaMK2b CaMK2g CaMK2d 90(57)
23CAMKCAMKLNuaK Novel (Nua) Kinase family NuaK1 NuaK2 1(1) -----
24CAMKCAMKLAMPK AMP-activated protein kinase AMPKa1 AMPKa2 37(28) 6497.180.683.14.4
25CAMKCAMKLCHK1 Checkpoint Kinase 1 CHK1 14(5) 68.893.881.375.33.7
26CAMKCAMKLCHK2 Checkpoint Kinase 2 CHK2 17(8) 49977385.93.5
27CAMKCAMKLLKB  LKB1 17(16) 73.710086.891.21.5
28CAMKCAMKLMARK Microtubule Affinity Regulating Kinase MARK1 MARK2 MARK3 MARK4 3(2) 6010080812.1
29CAMKCAMKLBRSK BRain Specific Kinase BRSK1 2(2) 100100100--
30CAMKDAPK Death Associated Protein Kinase DAPK1 DAPK2 DAPK3 DRAK1 DRAK2 24(15) 61.976.
31CAMKMAPKAPKMAPKAPK MAP Kinase Associated Protein Kinase MAPKAPK2 MAPKAPK3 MAPKAPK5 33(18) 66.782.974.877.63.4
32CAMKMAPKAPKMNK MAPK iNtegrating or iNteracting Kinase MNK1 MNK2 3(3) 010050--
33CAMKMLCK Myosin Light Chain Kinases smMLCK TTN caMLCK skMLCK Sgk085 6(5) 7510087.562.55.9
34CAMKPHK Phosphorylase Kinase PHKg1 PHKg2 16(8) 64.378.671.470.46.7
35CAMKPIM  PIM1 PIM2 PIM3 3(1) 66.710083.348.318.3
36CAMKPKD Protein Kinase D PKD1 PKD2 PKD3 10(6) 6010080808.5
37CK1CK1 Cell Kinase 1 CK1a CK1d CK1e CK1g2 CK1g3 CK1a2 CK1g1 88(42) 65.176.770.964.44.0
38CK1TTBK Tau Tubulin Kinase TTBK1 TTBK2 7(1) 71.485.778.659.35.9
39CK1VRK Vaccinia Related Kinase VRK1 VRK2 VRK3 4(2) 2010060515.7
40CMGCCDKCDK7 Cyclin Dependent Kinase subfamily 7 CDK7 18(12) 7595.885.483.13.9
41CMGCCDKCDC2 Cell Division Control 2 CDC2 CDK2 CDK3 329(139) 82.188.885.590.40.9
42CMGCCDK Cyclin Dependent Kinase CDK4 CDK5 CDK6 CDK8 CDK9 CDK10 CDK11 123(66) 82.491.186.793.91.4
43CMGCDYRKHIPK Homeodomain Interacting Protein Kinases HIPK1 HIPK2 HIPK3 HIPK4 2(2) 7510087.58014.7
44CMGCDYRKDyrk Dual-specificity Tyrosine Regulated Kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4 12(10) 66.783.37566.75.2
45CMGCGSK Gycogen Synthase 3 Kinase GSK3A GSK3B 80(46) 70.491.981.178.81.8
46CMGCMAPK Mitogen Activated Protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) NLK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 369(204) 81.48482.788.80.9
47CMGCMAPKJNK JNK subfamily of MAPK JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) 59(35) -----
48CMGCMAPKp38 p38 subfamily of MAPK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 60(33) -----
49CMGCMAPKERK Extracellular signal-Regulated protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) 167(107) -----
50OtherAUR Aurora Kinase AurA AurB AurC 55(26) -----
51OtherAURAurB Aurora Kinase B AurB 29(16) 84.680.882.781.53.6
52OtherAURAurA Aurora Kinase B AurA 28(12) 53.692.973.271.67.5
53OtherCAMKKMeta Metazoan-specific family of CAMK (Calcium/Calmodulin Regulated Kinase) Kinase CaMKK1 CaMKK2 2(2) 10010010096.77.0
54OtherCK2 Casein kinase II CK2a1 CK2a2  85.775.98781.484.3
55OtherIKK I kappa Kinase IKKa IKKb IKKe TBK1  68.958.17063.966.3
56OtherNEK Mitotic Kinase family, also known as NRK (NimA-Related Kinase, based on Aspergillus NimA) NEK1 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK8 NEK9 NEK10 NEK11  1002510062.566.9
57OtherKIS Kinase interacting with stathmin KIS  10066.710083.378.3
58OtherPEKPKR Interferon-induced, double-stranded RNA-activated protein kinase PKR  80758077.566.7
59OtherPEKHRI  HRI  100100100100-
60OtherPLK Polo Like Kinases PLK1 PLK2 PLK3 PLK4  61.85559.757.361.9
61OtherWEE Homologs of yeast Wee1; cell cycle kinase Wee1 Wee1B MYT1  nan010050-
62OtherWnk With No Lysine kinases. Missing the canonical catalytic lysine, instead using a nearby lysine for catalysis Wnk1 Wnk2 Wnk3 Wnk4  10066.710083.387.5
63OtherCDPK  CDPK  66.744.477.861.162.2
64STESTE11MAP3K MAP3K (MAP kinase kinase kinase) genes, homologous to yeast Ste 11 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8
65STESTE20MST  MST1 MST2  100401007061
66STESTE20PAK p21-Activated protein Kinase PAK1 PAK2 PAK3 PAK4 PAK5 PAK6  78.870.580.175.376.9
67STESTE7MAP2K MAP2K (MAP kinase kinase) genes, homologous to yeast Ste 7 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7  92.99093.191.480.7
68TKAbl Abelson murine leukemia homolog ABL1(Abl) ABL2(ARG)  74.366.976.771.866.3
69TKAlk Anaplastic Lymphoma Kinase ALK LTK  10033.310066.755.8
70TKAxl  AXL MER TYRO3  100501007558.3
71TKCsk C-SRC kinase CSK CTK  72.268.473.771.169.2
72TKEGFR Epidermal Growth Factor Receptor EGFR HER2/ErbB2 HER3/ErbB3 HER4/ErbB4  85.968.188.578.372.7
73TKEph Ephrin receptors EphA1 EphA2 EphA3 EphA4 EphA5 EphA6 EphA7 EphA8 EphA10 EphB1 EphB2 EphB3 EphB4 EphB5 EphB6  93.3709582.580.3
74TKFak Focal Adhesion Kinase FAK PYK2  9183.391.787.573.3
75TKFerFer Proto-oncogene tyrosine-protein kinase FER FER  100401007082
76TKFerFes Proto-oncogene tyrosine-protein kinase Fes/Fps FES  83.355.688.972.260.6
77TKFGFR Fibroblast Growth Factor Receptor FGFR1 FGFR2 FGFR3 FGFR4  73.746.783.36568.5
78TKInsRIGF1R Insulin-like growth factor I receptor IGF1R  92.38093.186.677.6
79TKInsR Insulin Receptor and associated Kinases INSR IRR  81.546.889.16864.5
80TKJAKJakA First (active) kinase domain of the dual-domain Janus Kinases JAK1 JAK2 JAK3  79.570.58175.776.9
81TKTYKTYK2 Non-receptor tyrosine-protein kinase TYK2  10062.510081.356.9
82TKMetMet Met proto-oncogene tyrosine kinase MET RON  10096.710098.392.7
83TKPDGFRFms Platelet-derived growth factor FMS  7585.771.478.669.3
84TKPDGFRFLT3 Platelet-derived growth factor FLT3 FLT3  10010010010080112.1
85TKPDGFRKit Platelet-derived growth factor KIT  1007510087.571.3
86TKPDGFR Platelet-derived growth factor PDGFRa PDGFRb 28(10) 76.562.569.565.56.2
87TKRet Proto-oncogene tyrosine-protein kinase receptor ret RET 14(3) 21.478.65047.16.9
88TKSrcBLK Proto-oncogene tyrosine-protein kinase BLK BLK 4(2) 7575758017.8
89TKSrcBrk Proto-oncogene tyrosine-protein kinase BRK BRK 4(2) 66.710083.38518.3
90TKSrcFgr Proto-oncogene tyrosine-protein kinase FGR FGR 8(4) 44.47559.752.513.5
91TKSrcFyn Proto-oncogene tyrosine-protein kinase FYN FYN 49(25) 66.9737066.65.6
92TKSrcHCK Proto-oncogene tyrosine-protein kinase HCK HCK 17(12) 2593.859.464.45.7
93TKSrcLck Proto-oncogene tyrosine-protein kinase Lck LCK 58(32) 7283.377.771.53.1
94TKSrcLYN Tyrosine-protein kinase LYN LYN 47(26) 56.380.968.666.83.7
95TKSrcSrc Proto-oncogene tyrosine-protein kinase Src SRC 162(96) 61.788.875.373.62.3
96TKSrcYES Proto-oncogene tyrosine-protein kinase YES YES 6(4) 33.310066.773.36.6
97TKSykSYK Spleen tyrosine kinase SYK 51(22) 7595.885.479.92.6
98TKSykZAP70 70 kDa zeta-associated protein, Syk-related tyrosine kinase ZAP70 20(9) 65958071.84.7
99TKTecBTK Bruton tyrosine kinase BTK 18(8) 57.185.771.466.47.2
100TKTecITK  ITK 7(4) 33.310066.767.512.6
101TKTecTXK Tyrosine-protein kinase TXK TXK TEC 7(5) 42.985.764.372.97.3
102TKTie Tunica interna endothelial cell kinase TIE1 TIE2 7(3) 85.710092.977.19.9
103TKTrk Neurotrophin receptor tyrosine kinases TRKA TRKB TRKC 13(4) 52.210076.188.85.2
104TKVEGFR Vascular Endothelial Growth Factor Receptors FLT1 FLT4 FLT3 KDR 23(6) 72.795.584.164.37.8
105TKLMLKILK Integrin Linked Kinase ILK 9(7) 501007578.23.6
106TKLRAF RAF proto-oncogene serine/threonine-protein kinase RAF1 ARAF BRAF KSR1 KSR2 5(3) ---58.813.2
107TKLSTKRTGFbR Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 1 TGFbR1 TGFbR2 12(3) 01005047.516.7