Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

The statistics of phosphorylated sites in the catagorized kinase families

All the 518 kinase genes, which were identified by Manning et al., are categorized by their annotated family or subfamily, including totally 221 kinase families. Because the collection of experimentally verified phosphorylated sites from PhosphoELM and SwissProt involved in various species, the number of phosphorylated sites in each kinase family is calculated in human and other species, as well as the number of phosphorylated proteins. Moreover, the sequence logo of each kinase family is presented by using Weblogo.

No.GroupFamilySubfamilyFamily descriptionKinase memberNumber of phosphosites in humanSequence logoNumber of phosphosites not in humanSequence logo
1AGCPKB Protein kinase B AKT1 AKT2 AKT3 89(63) 25(16) 
2AGCDMPKROCK Rho Kinase ROCK1 ROCK2 25(15) 16(10) 
3AGCDMPKGEK Genghis Khan DMPK1 DMPK2 MRCKa MRCKb 3(3) 2(2) 
4AGCDMPKCRIK Citron Rho-interacting kinase CRIK 0(0)  0(0)  
5AGCGRKGRK G-protein coupled Receptor Kinase GPRK7 RHOK GPRK6 GPRK5 GPRK4 64(19) 21(8) 
6AGCGRKBARK Beta Adrenergic Receptor Kinase BARK1 BARK2 32(14) 3(3) 
7AGCMASTMAST Microtubule Associated Serine/Threonine Kinase MAST1 MAST2 MAST3 MAST4 0(0)  0(0)  
8AGCMASTMASTL MAST like MASTL 0(0)  0(0)  
9AGCNDR Nuclear Dbf2-related kinases NDR1 NDR2 LATS1 LATS2 2(2) 0(0)  
10AGCPKA Protein kinase A PKACa PKACb PKACg 232(151) 226(135) 
11AGCPDK1 Phosphoinositide-dependent protein kinase PDK1 45(20) 9(8) 
12AGCPKC Protein kinase C PKCh PKCa PKCb PKCd PKCe PKCg PKCi PKCt PKCz 280(168) 205(106) 
13AGCPKCAlpha Protein kinase C, alpha PKCa PKCb PKCg 121(74) 25(17) 
14AGCPKCDelta Protein kinase C, delta PKCd PKCt 30(22) 2(2) 
15AGCPKCEta Protein kinase C, eta PKCe PKCh 14(12) 0(0)  
16AGCPKCIota Protein kinase C, iota PKCi PKCz 13(11) 4(3) 
17AGCPKG Protein kinase G PKG1 PKG2 25(15) 22(11) 
18AGCPKN Protein kinase N PKN1 PKN2 PKN3 0(0)  6(3) 
19AGCRSKRSK Ribosomal S6 Kinase RSK1 RSK2 RSK3 RSK4 40(31) 11(7) 
20AGCRSKp70 p70 subfamily of Ribosomal Specific Kinase p70S6K p70S6Kb 9(7) 0(0)  
21AGCRSKMSK Mitogen- and Stress-activated protein Kinase MSK1 MSK2 9(4) 3(1) 
22AGCRSKL RSK-like RSKL1 RSKL2 0(0)  0(0)  
23AGCRSKR RSK-related SgK494 0(0)  0(0)  
24AGCSGK Serum and Glucocorticoid Resposive Kinase SGK SGK2 SGK3 19(10) 5(3) 
25AGCYANK Yet Another Novel Kinase YANK1 YANK2 YANK3 0(0)  0(0)  
26AtypicalABC1 ABC1 atypical kinases ADCK1 ADCK2 ADCK3 ADCK4 ADCK5 0(0)  0(0)  
27AtypicalAlphaAlpha Ancient family of atypical kinases AlphaK1 AlphaK2 AlphaK3 0(0)  0(0)  
28AtypicalAlphaeEF2K Eukaryotic Elongation Factor 2 Kinase eEF2K 1(1) 0(0)  
29AtypicalAlphaChaK Channel Kinase ChaK1 ChaK2 1(1) 2(1) 
30AtypicalBCR Breakpoint Cluster Region kinase BCR 0(0)  0(0)  
31AtypicalBRD Bromodomain containing kinases BRDT BRD2 BRD3 BRD4 0(0)  0(0)  
32AtypicalFAST  FASTK 0(0)  0(0)  
33AtypicalG11  G11(STK19) 0(0)  0(0)  
34AtypicalH11  H11 0(0)  0(0)  
35AtypicalPDHKPDHK Pyruvate Dehydrogenase Kinase PDHK1 PDHK2 PDHK3 PDHK4 BCKDK 2(1) 2(1) 
36AtypicalPDHKBCKDK Branched Chain Ketoacid Dehydrogenase Kinase BCKDK 0(0)  2(1) 
37AtypicalPIKKTRRAP TRansactivation/tRansformation-domain Associated Protein TRRAP 0(0)  0(0)  
38AtypicalPIKKSMG1  SMG1 0(0)  0(0)  
39AtypicalPIKKATM Ataxia telangiectasia mutated ATM ATR 67(34) 35(29) 
40AtypicalPIKKDNAPK DNA Protein Kinase DNAPK 25(13) 10(6) 
41AtypicalPIKKFRAP FKBP12-rapamycin-associated protein FRAP 14(4) 1(1) 
42AtypicalRIO  RIOK1 RIOK2 RIOK3 0(0)  0(0)  
43AtypicalTAF1  TAF1 TAF1L 5(2) 1(1) 
44AtypicalTIF1 Transcriptional Intermediary Factor TIF1a TIF1b TIF1b 0(0)  0(0)  
45CAMKCAMK-Unique  VACAMKL STK33 0(0)  0(0)  
46CAMKCAMK1 CAMK family 1 CaMK1a CaMK1b CaMK1g CaMK1d CaMK4 18(14) 8(8) 
47CAMKCAMK2 CAMK family 2 CaMK2a CaMK2b CaMK2g CaMK2d 56(36) 63(41) 
48CAMKCAMKLNIM1  NIM1 0(0)  0(0)  
49CAMKCAMKLNuaK Novel (Nua) Kinase family NuaK1 NuaK2 4(4) 2(2) 
50CAMKCAMKLPASK PAS domain Kinase PASK 2(1) 0(0)  
51CAMKCAMKLQIK Qin Induced Kinase QIK QSK SIK 1(1) 0(0)  
52CAMKCAMKLSNRK  SNRK 0(0)  0(0)  
53CAMKCAMKLMELK Maternal Embryonic Leucine zipper Kinase MELK 2(1) 0(0)  
54CAMKCAMKLAMPK AMP-activated protein kinase AMPKa1 AMPKa2 18(14) 20(14) 
55CAMKCAMKLCHK1 Checkpoint Kinase 1 CHK1 11(6) 5(1) 
56CAMKCAMKLCHK2 Checkpoint Kinase 2 CHK2 12(6) 21(5) 
57CAMKCAMKLHUNK Hormonally Upregulated Neu-associated Kinase HUNK 0(0)  0(0)  
58CAMKCAMKLLKB  LKB1 17(16) 3(2) 
59CAMKCAMKLMARK Microtubule Affinity Regulating Kinase MARK1 MARK2 MARK3 MARK4 7(2) 3(2) 
60CAMKCAMKLBRSK BRain Specific Kinase BRSK1 3(3) 0(0)  
61CAMKCASK calcium/calmodulin-dependent serine protein kinase CASK 0(0)  0(0)  
62CAMKDAPK Death Associated Protein Kinase DAPK1 DAPK2 DAPK3 DRAK1 DRAK2 17(10) 7(5) 
63CAMKDCAMKL Doublecortin and CaMK-Like DCLK1 DCLK2 DCLK3 0(0)  0(0)  
64CAMKMAPKAPKMAPKAPK MAP Kinase Associated Protein Kinase MAPKAPK2 MAPKAPK3 MAPKAPK5 25(16) 11(4) 
65CAMKMAPKAPKMNK MAPK iNtegrating or iNteracting Kinase MNK1 MNK2 1(1) 2(2) 
66CAMKMLCK Myosin Light Chain Kinases smMLCK TTN caMLCK skMLCK Sgk085 3(2) 7(5) 
67CAMKPHK Phosphorylase Kinase PHKg1 PHKg2 9(5) 11(6) 
68CAMKPIM  PIM1 PIM2 PIM3 1(1) 2(1) 
69CAMKPKD Protein Kinase D PKD1 PKD2 PKD3 7(6) 6(3) 
70CAMKPSK Protein Serine Kinase PSKH1 PSKH2 0(0)  0(0)  
71CAMKSgK495  SgK495 0(0)  0(0)  
72CAMKTrbl tribbles Trb1 Trb2 Trb3 0(0)  0(0)  
73CAMKTrio  Trad Trio SPEG Obscn 0(0)  0(0)  
74CAMKTSSK Testis Specific Serine Kinase  TSSK1 TSSK2 TSSK3 TSSK4 SSTK 0(0)  1(1) 
75CK1CK1 Cell Kinase 1 CK1a CK1d CK1e CK1g2 CK1g3 CK1a2 CK1g1 63(33) 38(19) 
76CK1TTBK Tau Tubulin Kinase TTBK1 TTBK2 7(1) 0(0)  
77CK1VRK Vaccinia Related Kinase VRK1 VRK2 VRK3 5(3) 0(0)  
78CMGCCDKCDK Cyclin Dependent Kinase CDK4 CDK5 CDK6 CDK8 CDK9 CDK10 CDK11 64(34) 59(32) 
79CMGCCDKCDK7 Cyclin Dependent Kinase subfamily 7 CDK7 17(11) 13(11) 
80CMGCCDKCDC2 Cell Division Control 2 CDC2 CDK2 CDK3 226(95) 102(43) 
81CMGCCDKCRK7  CHED CRK7 0(0)  0(0)  
82CMGCCDKPCTAIRE  PCTAIRE1 PCTAIRE2 PCTAIRE3 0(0)  1(1) 
83CMGCCDKPFTAIRE  PFTAIRE1 PFTAIRE2 0(0)  0(0)  
84CMGCCDKPITSLRE  PITSLRE 0(0)  0(0)  
85CMGCCDKL Cyclin Dependent Kinase Like CDKL1 CDKL2 CDKL3 CDKL4 CDKL5 0(0)  0(0)  
86CMGCCK2 Casein kinase II CK2a1 CK2a2 CK2al-rs 241(123) 127(69) 
87CMGCCLK CDC-Like Kinase, involved in splicing CLK1 CLK2 CLK3 CLK4 1(1) 0(0)  
88CMGCDYRKPRP4  PRP4 1(1) 0(0)  
89CMGCDYRKHIPK Homeodomain Interacting Protein Kinases HIPK1 HIPK2 HIPK3 HIPK4 3(3) 1(1) 
90CMGCDYRKDYRK Dual-specificity Tyrosine Regulated Kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4 9(7) 4(4) 
91CMGCGSK Gycogen Synthase 3 Kinase GSK3A GSK3B 56(34) 31(16) 
92CMGCMAPKMAPK Mitogen Activated Protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) NLK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 248(140) 85(52) 
93CMGCMAPKJNK JNK subfamily of MAPK JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) 47(27) 19(13) 
94CMGCMAPKp38 p38 subfamily of MAPK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 62(35) 4(3) 
95CMGCMAPKERK Extracellular signal-Regulated protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) 138(88) 40(24) 
96CMGCMAPKnmo nemo NLK 2(1) 0(0)  
97CMGCRCK  MAK MOK ICK 1(1) 0(0)  
98CMGCSRPK SR Protein Kinase; phosphorylates SR splicing factors MSSK1 SRPK1 SRPK2 0(0)  0(0)  
99OtherAURAur Aurora Kinase AurA AurB AurC 42(19) 15(9) 
100OtherAURAurB Aurora Kinase B AurB 21(12) 9(5) 
101OtherAURAurA Aurora Kinase B AurA 23(9) 6(4) 
102OtherBUB  BUB1 BUBR1 0(0)  0(0)  
103OtherBud32  PRPK 1(1) 0(0)  
104OtherCAMKKMeta Metazoan-specific family of CAMK (Calcium/Calmodulin Regulated Kinase) Kinase CaMKK1 CaMKK2 3(3) 1(1) 
105OtherCDC7 Cell Division Control 7 CDC7 2(1) 0(0)  
106OtherHaspin  Haspin 0(0)  0(0)  
107OtherIKK I kappa Kinase IKKa IKKb IKKe TBK1 43(12) 6(4) 
108OtherIRE Inositol REquiring  IRE1 IRE2 0(0)  1(1) 
109OtherMOS  MOS 0(0)  2(1) 
110OtherKIS Kinase interacting with stathmin KIS 3(3) 1(1) 
111OtherNAK Numb-Associated Kinase MPSK1 GAK BIKE AAK1 0(0)  0(0)  
112OtherNEK Mitotic Kinase family, also known as NRK (NimA-Related Kinase, based on Aspergillus NimA) NEK1 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK8 NEK9 NEK10 NEK11 8(6) 5(1) 
113OtherNKF1 New Kinase Family 1 SgK110 SgK069 SBK 0(0)  0(0)  
114OtherNKF2 New Kinase Family 2 PINK1 0(0)  0(0)  
115OtherNKF3 New Kinase Family 3 SgK269 SgK223 0(0)  0(0)  
116OtherNKF4 New Kinase Family 4 CLIK1 CLIK1L 0(0)  0(0)  
117OtherNKF5 New Kinase Family 5 SgK307 SgK424 0(0)  0(0)  
118OtherNRBP Nuclear Receptor Binding Protein NRBP1 NRBP2 0(0)  0(0)  
119OtherOther-Unique  RNAseL SgK396 SgK196 0(0)  0(0)  
120OtherPEKGCN2 General Control Non-derepressible GCN2 0(0)  2(2) 
121OtherPEKPKR Interferon-induced, double-stranded RNA-activated protein kinase PKR 13(4) 4(2) 
122OtherPEKPEK Pancreatic eIF-2alpha Kinase  PEK 0(0)  0(0)  
123OtherPEKHRI Heme-Regulated Inhibitor kinase  HRI 2(1) 2(2) 
124OtherPLK Polo Like Kinases PLK1 PLK2 PLK3 PLK4 46(18) 4(3) 
125OtherSCY1  SCYL1 SCYL2 SCYL3 0(0)  0(0)  
126OtherSgK071  SgK071 0(0)  0(0)  
127OtherSgK493  SgK493 0(0)  0(0)  
128OtherSgK496  SgK496 0(0)  0(0)  
129OtherSlob Named after the first member, Drosophila SLOw Borders Slob 0(0)  0(0)  
130OtherTBCK TBC domain-containing Kinase TBCK 0(0)  0(0)  
131OtherTLK Tousled-Like Kinase TLK1 TLK2 0(0)  0(0)  
132OtherTOPK T-cell Originated Kinase, also known as PBK (PDZ domain-binding kinase) PBK 0(0)  0(0)  
133OtherTTK  TTK 0(0)  0(0)  
134OtherULKULK Unc-51 Like Kinase ULK1 ULK2 ULK3 ULK4 0(0)  0(0)  
135OtherULKFused  Fused 0(0)  0(0)  
136OtherVPS15  PIK3R4 1(1) 0(0)  
137OtherWEE Homologs of yeast Wee1; cell cycle kinase Wee1 Wee1B MYT1 2(2) 1(1) 
138OtherWNK With No Lysine kinases. Missing the canonical catalytic lysine, instead using a nearby lysine for catalysis Wnk1 Wnk2 Wnk3 Wnk4 4(2) 2(1) 
139OtherCDPK  CDPK 3(3) 6(5) 
140RGCRGC Receptor Guanylate Cyclases ANPa ANPb CYGD CYGF HSER 0(0)  0(0)  
141STESTE-Unique  COT NIK 3(2) 0(0)  
142STESTE11MAP3K MAP3K (MAP kinase kinase kinase) genes, homologous to yeast Ste 11 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 17(10) 5(4) 
143STESTE20PAK p21-Activated protein Kinase PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 34(25) 25(12) 
144STESTE20PAKB Class B p21-Activated protein Kinase PAK4 PAK5 PAK6 1(1) 0(0)  
145STESTE20PAKA Class A p21-Activated protein Kinase PAK1 PAK2 PAK3 29(23) 25(12) 
146STESTE20SLK Ste20-Like Kinase  LOK SLK 1(1) 0(0)  
147STESTE20STLK Serine Threonine Like Kinase STLK5 STLK6 STLK6-rs 0(0)  2(1) 
148STESTE20TAO Thousand and One Kinase, whose sequence was 1001 AA long. Also known as the SULU family TAO1 TAO3 TAO3 0(0)  0(0)  
149STESTE20YSK Yeast SPS1/STE20-like kinase YSK1 MST3 MST4 1(1) 0(0)  
150STESTE20KHS Kinase Homologous to STE20 KHS1 KHS2 GCK HPK1 3(3) 0(0)  
151STESTE20FRAY  STLK3 OSR1 0(0)  3(2) 
152STESTE20MSN misshapen HGK TNIK NRK MINK 1(1) 0(0)  
153STESTE20MST Mammalian STE20-like kinase MST1 MST2 21(20) 13(12) 
154STESTE20NinaC  MYO3A MYO3B 0(0)  0(0)  
155STESTE7MAP2K MAP2K (MAP kinase kinase) genes, homologous to yeast Ste 7 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 29(13) 1(1) 
156TKAbl Abelson murine leukemia homolog ABL1(Abl) ABL2(ARG) 36(26) 20(13) 
157TKAck Activated Cdc42-associated tyrosine kinase ACK TNK1 1(1) 0(0)  
158TKALK Anaplastic Lymphoma Kinase ALK LTK 6(3) 0(0)  
159TKAxl  AXL MER TYRO3 6(2) 0(0)  
160TKCCK4 Colon Carcinoma Kinase 4 CCK4 0(0)  0(0)  
161TKCsk C-SRC kinase CSK CTK 19(8) 3(3) 
162TKDDR Discoidin Domain Receptor kinase DDR1 DDR2 1(1) 12(10) 
163TKEGFR Epidermal Growth Factor Receptor EGFR ErbB2 ErbB3 ErbB4 48(22) 19(7) 
164TKEph Ephrin receptors EphA1 EphA2 EphA3 EphA4 EphA5 EphA6 EphA7 EphA8 EphA10 EphB1 EphB2 EphB3 EphB4 EphB5 EphB6 11(7) 11(6) 
165TKFAK Focal Adhesion Kinase FAK PYK2 9(6) 6(6) 
166TKFerFer Proto-oncogene tyrosine-protein kinase FER FER 0(0)  5(2) 
167TKFerFes Proto-oncogene tyrosine-protein kinase Fes/Fps FES 7(2) 2(1) 
168TKFGFR Fibroblast Growth Factor Receptor FGFR1 FGFR2 FGFR3 FGFR4 30(8) 0(0)  
169TKInsR Insulin Receptor and associated Kinases INSR IRR 30(9) 16(5) 
170TKInsRIGF1R Insulin-like growth factor I receptor IGF1R 11(3) 20(4) 
171TKJAKJakA First (active) kinase domain of the dual-domain Janus Kinases JAK1 JAK2 JAK3 29(17) 17(5) 
172TKTYKTYK2 Non-receptor tyrosine-protein kinase TYK2 7(4) 1(1) 
173TKLmr Lemur Kinase LMR1 LMR2 LMR3 0(0)  0(0)  
174TKMetMet Met proto-oncogene tyrosine kinase MET RON 19(4) 12(2) 
175TKMusk Muscle-Specific Kinase MUSK 0(0)  0(0)  
176TKPDGFRPDGFR Platelet-derived growth factor PDGFRa PDGFRb 30(10) 2(2) 
177TKPDGFRFms Platelet-derived growth factor, FMS FMS 2(1) 6(1) 
178TKPDGFRFLT3 Fms-Like Tyrosine kinase FLT3 4(1) 0(0)  
179TKPDGFRKit Platelet-derived growth factor KIT 4(1) 0(0)  
180TKRet Proto-oncogene tyrosine-protein kinase receptor ret RET 14(3) 0(0)  
181TKRor Regeneron Orphan Receptors ROR1 ROR2 0(0)  0(0)  
182TKRyk Receptor Tyrosine Kinase RYK 0(0)  0(0)  
183TKSev Named after Drosophila sevenless, a receptor tyrosine kinase involved in eye cell fate determination ROS 0(0)  0(0)  
184TKSrcSRM Proto-oncogene tyrosine-protein kinase SRM SRM 0(0)  0(0)  
185TKSrcBLK Proto-oncogene tyrosine-protein kinase BLK BLK 4(2) 0(0)  
186TKSrcBrk Proto-oncogene tyrosine-protein kinase BRK BRK 4(2) 0(0)  
187TKSrcFgr Proto-oncogene tyrosine-protein kinase FGR FGR 4(3) 4(1) 
188TKSrcFyn Proto-oncogene tyrosine-protein kinase FYN FYN 37(21) 19(10) 
189TKSrcHCK Proto-oncogene tyrosine-protein kinase HCK HCK 9(7) 8(5) 
190TKSrcLck Proto-oncogene tyrosine-protein kinase Lck LCK 48(25) 16(11) 
191TKSrcLYN Tyrosine-protein kinase LYN LYN 33(20) 17(8) 
192TKSrcSrc Proto-oncogene tyrosine-protein kinase Src SRC 108(68) 63(33) 
193TKSrcYES Proto-oncogene tyrosine-protein kinase YES YES 3(2) 3(2) 
194TKSrcFrk Fyn-related kinase FRK 0(0)  0(0)  
195TKSykSYK Spleen tyrosine kinase SYK 38(17) 13(5) 
196TKSykZAP70 70 kDa zeta-associated protein, Syk-related tyrosine kinase ZAP70 16(8) 4(1) 
197TKTec Tec protein tyrosine kinase family TXK TEC ITK BMX BTK 26(13) 4(1) 
198TKTecBTK Bruton tyrosine kinase BTK 14(7) 4(1) 
199TKTecITK IL2-inducible T-cell kinase ITK 7(4) 0(0)  
200TKTecTXK Tyrosine-protein kinase TXK TXK TEC 7(5) 0(0)  
201TKTie Tunica interna endothelial cell kinase TIE1 TIE2 5(1) 2(2) 
202TKTK-Unique  SuRTK106 0(0)  0(0)  
203TKTrk Neurotrophin receptor tyrosine kinases TRKA TRKB TRKC 5(1) 8(3) 
204TKVEGFR Vascular Endothelial Growth Factor Receptors FLT1 FLT4 FLT3 KDR 22(5) 1(1) 
205TKLIRAK IL1 Receptor Associated Kinase IRAK1 IRAK2 IRAK3 IRAK4 4(2) 0(0)  
206TKLLISKTESK TEstis Specific Kinase TESK1 TESK2 1(1) 0(0)  
207TKLLISKLIMK LIM domain containing kinase LIMK1 LIMK2 2(2) 0(0)  
208TKLLRRK Leucine Rich Repeat Kinase LRRK1 LRRK2 0(0)  0(0)  
209TKLMLKMLK Mixed Lineage Kinase MLK1 MLK2 MLK3 MLK4 3(2) 0(0)  
210TKLMLKLZK Leucine zipper-bearing kinase  LZK DLK 0(0)  0(0)  
211TKLMLKZAK Sterile alpha motif and leucine zipper containing kinase AZK ZAK 1(1) 0(0)  
212TKLMLKTAK1 Transforming growth factor-]-activated kinase 1 TAK1 0(0)  0(0)  
213TKLMLKHH498  HH498 0(0)  0(0)  
214TKLMLKILK Integrin Linked Kinase ILK 6(6) 5(3) 
215TKLRAFRAF RAF proto-oncogene serine/threonine-protein kinase RAF1 ARAF BRAF 3(2) 2(1) 
216TKLRAFKSR Kinase Suppressor of Ras KSR1 KSR2 1(1) 0(0)  
217TKLRIPK Receptor Interacting Protein Kinases RIPK1 RIPK2 RIPK3 SgK288 ANKRD3 0(0)  0(0)  
218TKLSTKRType1 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 1 TGFbR1 ALK7 ALK1 ALK2 ALK4 BMPR1A BMPR1B 6(2) 0(0)  
219TKLSTKRType2 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 2 TGFbR2 BMPR2 MISR2 ACTR2 ACTR2B 6(1) 0(0)  
220TKLSTKRTGFbR Serine/Threonine Kinase Receptors; receptors for TGFb ligands TGFbR1 TGFbR2 12(3) 0(0)  
221TKLTKL-Unique  MLKL 0(0)  0(0)